IMMUNOBIOLOGY Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance
نویسندگان
چکیده
1Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD; 2Biostatistics Research Branch, SAIC-Frederick Inc, NCI-Frederick, Frederick, MD; 3Biostatistics Research Branch, NIAID, Bethesda, MD; 4Division of AIDS, NIAID, Bethesda, MD; 5Applied/Developmental Research Directorate, SAIC-Frederick Inc, Frederick, MD; 6Division of Clinical Research, NIAID, Bethesda, MD; 7Radiopharmaceutical Laboratory, Nuclear Medicine, Radiology and Imaging Sciences, Clinical Center, Bethesda, MD; and 8Battelle/Charles River–Integrated Research Facility–NIAID Frederick, National Institutes of Health, Bethesda, MD
منابع مشابه
Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance.
IL-7 is essential for T-cell homeostasis. Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought to be due to increased production by homeostatic feedback, decreased receptor-mediated clearance, or both. The goal of this study was to understand how immune reconstitution through antiretroviral therapy (ART) in HIV(+) patients affects IL-7 serum levels, expression ...
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